Autoregulation of GFR

  1. Myogenic mechanism:
    • Myogenic reflex is primarily mediated by prostaglandins
    • Myogenic reflex is inhibited by NSAIDs.
  2. Tubuloglomerular feedback:
    • Tubuloglomerular feedback is primarily mediated by levels of NO
    • Tubuloglomerular feedback is inhibited by Cyclosporin.

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