CADASIL

4.8
(6)
  • Most common form of hereditary stroke disorder
  • Full form: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
  • Pathogenesis: Mutation in NOTCH3 gene
  • Remember: CADASIL: NOTCH3
  • Age: Young and middle age
  • C/F:
    1. Recurrent lacunar and subcortical white matter ischemic strokes
    2. Vascular dementia
  • MRI finding: Widespread confluent white matter hyperintensities
  • Location: Anterior temporal lobe and external capsule.

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