Darrow Yannet diagram

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Introduction:

  • A Darrow Yannet diagram (D-Y diagram) is a schematic used in physiology to identify how the volumes of extracellular fluid and intracellular fluid alter in response to clinical conditions
  • X axis represents volume
  • Y axis represents solute osmolarity.

Principles:

  1. Addition or loss of fluid occurs from the ECF only
  2. ECF osmolality determines the shift of fluid
  3. Shift of fluid occurs till osmolality of ECF & ICF are same.

6 types of diagrams:

Addition of isotonic fluid

Volume

Osmolality

ECF

Same
ICF Same

Same

Addition of hypotonic fluid

Ex: SIADH

Volume

Osmolality

ECF

ICF

Addition of hypertonic fluid

Volume

Osmolality

ECF

ICF

Loss of isotonic fluid

Ex: Hemorrhage/ Burns

Volume

Osmolality

ECF

Same
ICF Same

Same

Loss of hypotonic fluid

Ex: Diabetes insipidus (ADH deficiency)

Volume

Osmolality

ECF

ICF

Loss of hypertonic fluid

Ex: Addison’s disease (mineralocorticoid deficiency)

Volume

Osmolality

ECF

ICF

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