Energetics of Glycolysis & Kreb’s cycle

4.3
(7)

Glycolysis

Step no.

Enzyme

ATP
1 Hexokinase

-1 ATP

3

PFK1 -1 ATP
5 G3PDH (2 NADH)

+5 ATP*

6

BPG-kinase +2 ATP
9 Pyruvate kinase

+2 ATP

Total

+7 ATP

 

Kreb’s cycle

Step no.

Enzyme

ATP
3 Isocitrate dehydrogenase (NADH)

+2.5

4

AKG dehydrogenase (NADH) +2.5
5 Succinate thiokinase (GTP)

+1

6

Succinate dehydrogenase (FADH2)

+1.5
8

Malate dehydrogenase (NADH)

+2.5

Total

+10 ATP

Summary:

  • Glycolysis: 7 ATP (G is the 7th letter)
  • Kreb’s cycle: 10 ATP (TCA = TEN)
  • Remember: 1 molecule of glucose cycles 2 times in TCA cycle (from 2 molecules of Pyruvate); giving rise to a total of 20 ATPs.

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